The applicants have published substantially in this and related areas. Here are a selection of that work:

Systematic reviews - Stroke

Title Authors Journal Details
Stem cell-based therapy for experimental stroke: A systematic review and meta-analysis. Lees JS, Sena ES, Egan KJ, Antonic A, Koblar SA, Howells DW, Macleod MR. Int J Stroke. 2012 Oct; 7(7):582-8. doi: 10.1111/j.1747-4949.2012.00797.x. Epub 2012 Jun 12.
Exploring the Efficacy of Constraint in Animal Models of Stroke: Meta-analysis and Systematic Review of the Current Evidence. Janssen H, Speare S, Spratt NJ, Sena ES, Ada L, Hannan AJ, McElduff P, Bernhardt J. Neurorehabil Neural Repair. 2012 Jun 19.
Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. Sena ES, Briscoe CL, Howells DW, Donnan GA, Sandercock PA, Macleod MR. J Cereb Blood Flow Metab. 2010 Dec;30(12):1905-13.
An enriched environment improves sensorimotor function post-ischemic stroke. Janssen H, Bernhardt J, Collier JM, Sena ES, McElduff P, Attia J, Pollack M, Howells DW, Nilsson M, Calford MB, Spratt NJ. Neurorehabil Neural Repair. 2010 Nov-Dec;24(9):802-13
A systematic review and meta-analysis of erythropoietin in experimental stroke. Jerndal M, Forsberg K, Sena ES, Macleod MR, O'Collins VE, Linden T, Nilsson M, Howells DW. J Cereb Blood Flow Metab. 2010 May;30(5):961-8.
Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke. Banwell V, Sena ES, Macleod MR. J Stroke Cerebrovasc Dis. 2009 Jul-Aug;18(4):269-76.
Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Macleod MR, van der Worp HB, Sena ES, Howells DW, Dirnagl U, Donnan GA. Stroke. 2008 Oct;39(10):2824-9.
A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke. Wheble PC, Sena ES, Macleod MR. Cerebrovasc Dis. 2008;25(1-2):5-11.
Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Brain. 2007 Dec;130(Pt 12):3063-74.
Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. Macleod MR, O'Collins T, Horky LL, Howells DW, Donnan GA. J Pineal Res. 2005 Jan;38(1):35-41. Review.
Pooling of animal experimental data reveals influence of study design and publication bias. Macleod MR, O'Collins T, Howells DW, Donnan GA. Stroke. 2004 May;35(5):1203-8. Epub 2004 Apr 1.

Systematic reviews of different neuroscience domains

Title Authors Journal Details
Evaluation of combination therapy in animal models of cerebral ischemia. O'Collins VE, Macleod MR, Donnan GA, Howells DW. J Cereb Blood Flow Metab. 2012 Apr;32(4):585-97. doi: 10.1038/jcbfm.2011.203. Epub 2012 Feb 1. Review.
Dopamine agonists in animal models of Parkinson's disease: a systematic review and meta-analysis. Rooke ED, Vesterinen HM, Sena ES, Egan KJ, Macleod MR. Parkinsonism Relat Disord. 2011 Jun;17(5):313-20.
Treatment of intracerebral hemorrhage in animal models: meta-analysis. Frantzias J, Sena ES, Macleod MR, Al-Shahi Salman R. Ann Neurol. 2011 Feb;69(2):389-99.
Improving the translational hit of experimental treatments in multiple sclerosis. Vesterinen HM, Sena ES, ffrench-Constant C, Williams A, Chandran S, Macleod MR. Mult Scler. 2010 Sep;16(9):1044-55.
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma. Amarasingh S, Macleod MR, Whittle IR. J Neurooncol. 2009 Jan;91(2):117-25

Opinion/Editorial

Title Authors Journal Details
International, multicenter randomized preclinical trials in translational stroke research: it's time to act. Dirnagl U, Fisher M. J Cereb Blood Flow Metab. 2012 Jun;32(6):933-5. doi: 10.1038/jcbfm.2012.51.
Translational research. Howells DW, Macleod MR. Int J Stroke. 2012 Jul;7(5):367-8. doi: 10.1111/j.1747-4949.2012.00817_2.x.
Preclinical studies of human disease: time to take methodological quality seriously. Van der Worp HB, Macleod MR. J Mol Cell Cardiol. 2011 Oct;51(4):449-50.
Why animal research needs to improve. Macleod M. Nature. 2011 Sep 28;477(7366):511.
Improving the quality of biomedical research: guidelines for reporting experiments involving animals. Dirnagl U, Lauritzen M. J Cereb Blood Flow Metab. 2011 Apr;31(4):989-90.
Animal models of neurological disease: are there any babies in the bathwater? Macleod M, van der Worp HB. Pract Neurol. 2010 Dec;10(6):312-4.
Fighting publication bias: introducing the Negative Results section. Dirnagl U, Lauritzen M. J Cereb Blood Flow Metab. 2010 Jul;30(7):1263-4.
Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke. Bath PM, Macleod MR, Green AR. Int J Stroke. 2009 Dec;4(6):471-9.
Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice. Dirnagl U, Macleod MR. Br J Pharmacol. 2009 Aug;157(7):1154-6.
Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M; STAIR VI Consortium. Stroke. 2009 Jul;40(7):2594-600
Update of the stroke therapy academic industry roundtable preclinical recommendations. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH; STAIR Group. Stroke. 2009 Jun;40(6):2244-50.
Improving outcome after stroke: overcoming the translational roadblock. Endres M, Engelhardt B, Koistinaho J, Lindvall O, Meairs S, Mohr JP, Planas A, Rothwell N, Schwaninger M, Schwab ME, Vivien D, Wieloch T, Dirnagl U. Cerebrovasc Dis. 2008;25(3):268-78.
Bench to bedside: the quest for quality in experimental stroke research. Dirnagl U. J Cereb Blood Flow Metab. 2006 Dec;26(12):1465-78.
Stroke research priorities for the next decade--A representative view of the European scientific community. Meairs S, Wahlgren N, Dirnagl U, Lindvall O, Rothwell P, Baron JC, Hossmann K, Engelhardt B, Ferro J, McCulloch J, Kaste M, Endres M, Koistinaho J, Planas A, Vivien D, Dijkhuizen R, Czlonkowska A, Hagen A, Evans A, De Libero G, Nagy Z, Rastenyte D, Reess J, Davalos A, Lenzi GL, Amarenco P, Hennerici M. Cerebrovasc Dis. 2006;22(2-3):75-82.

Improving translational medicine

Title Authors Journal Details
Improving the efficiency of the development of drugs for stroke. Howells DW, Sena ES, O'Collins V, Macleod MR. Int J Stroke. 2012 Jul;7(5):371-7. doi: 10.1111/j.1747-4949.2012.00805.x.
Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study. Richter SH, Garner JP, Zipser B, Lewejohann L, Sachser N, Touma C, Schindler B, Chourbaji S, Brandwein C, Gass P, van Stipdonk N, van der Harst J, Spruijt B, Võikar V, Wolfer DP, Würbel H. PLoS One. 2011 Jan 31;6(1):e16461.
Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable. Schlattmann P, Dirnagl U. J Cereb Blood Flow Metab. 2010 Sep;30(9):1558-63.
Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia. Howells DW, Porritt MJ, Rewell SS, O'Collins V, Sena ES, van der Worp HB, Traystman RJ, Macleod MR. J Cereb Blood Flow Metab. 2010 Aug;30(8):1412-31.
Can animal models of disease reliably inform human studies? van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O'Collins V, Macleod MR. PLoS Med. 2010 Mar 30;7(3):e1000245.
Statistics in experimental cerebrovascular research-comparison of two groups with a continuous outcome variable. Schlattmann P, Dirnagl U. J Cereb Blood Flow Metab. 2010 Mar;30(3):474-9.
Systematic variation improves reproducibility of animal experiments. Richter SH, Garner JP, Auer C, Kunert J, Würbel H. Nat Methods. 2010 Mar;7(3):167-8.
Environmental standardization: cure or cause of poor reproducibility in animal experiments? Richter SH, Garner JP, Würbel H. Nat Methods. 2009 Apr;6(4):257-61.
Good laboratory practice: preventing introduction of bias at the bench. Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman R, Minematsu K, Donnan GA, Howells DW. Stroke. 2009 Mar;40(3):e50-2
How can we improve the pre-clinical development of drugs for stroke? Sena E, van der Worp HB, Howells D, Macleod M. Trends Neurosci. 2007 Sep;30(9):433-9.

Improving translational medicine

Title Authors Journal Details
Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism. Vesterinen HM, Egan K, Deister A, Schlattmann P, Macleod MR, Dirnagl U. J Cereb Blood Flow Metab. 2011 Apr;31(4):1064-72. Epub 2010
Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. Sena ES, van der Worp HB, Bath PM, Howells DW, Macleod MR. PLoS Biol. 2010 Mar 30;8(3):e1000344.
1,026 experimental treatments in acute stroke. O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. Ann Neurol. 2006 Mar;59(3):467-77.
Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia. van der Worp HB, de Haan P, Morrema E, Kalkman CJ. J Neurol. 2005 Sep;252(9):1108-14.

The Multi-PART collaborators met in Edinburgh in September, 2013 for a kick-off meeting. As part of our committment to openness and transparency and in support of pre-competitive partnerships we are making the Multi-PART proposal available. We would be delighted to have your feedback, or expressions of interest in being part of Multi-PART, and these should be sent to Emily Sena, the project coordinator.

Meeting at Edinbrugh, UK August 2015

Title Presentor
Multi-PART - Our Story Emily Sena
WP1: Project management David Howells and Bart van der Worp
WP1: Project management - Fundding David Howells
WP2: Scientific Coordination Uli Dirnagl & Mhairi Macrae
WP3: Experimental Design Hanno Würbel & Denis Vivien
WP4: Regulation and Ethics Stuart Allan & Nathalie Percie du Sert
WP5: Data Management Malcolm Macleod
WP6: Statistics Analysis Philip Bath & Joan Montaner
WP6: Statistics Analysis - Lessons from planning a beta test Becky Trueman

Meeting at Utrecht, Netherlands March 2015

Title Presentor
Multi-PART - RAtionale & Purpose Emily Sena
WP1: Project management Bart van der Worp
WP2: Scientific Coordination Uli Dirnagl & Mhairi Macrae
WP3: Experimental Design Hanno Würbel & Denis Vivien
WP4: Regulation and Ethics Stuart Allan & Nathalie Percie du Sert
WP4: Regulation and Ethics - pre meeting Nathalie Percie du Sert
WP5: Data Management - Live Presentation of Multi-PART Web Application Malcolm Macleod

Meeting at Barcelona, Spain October 2014

Title Presentor
Multi-PART Rationale & Purpose Emily Sena
WP1: Project management - training and dissemination Delphi Results Bart van der Worp
WP2: Scientific Coordination SOPs & Survey Results Uli Dirnagl & Mhairi Macrae
WP3: Experimental Design - Heterogeneity Hanno Würbel
WP3: Experimental Design - MRI protocols Xenios Milidonis
WP4: Regulation and Ethics - Mock Ethics Application Stuart Allan
WP4: Regulation and Ethics Nathalie Percie du Sert
WP5: Data Management - Database development Jing Liao
WP6: Statistical Analysis - Statistical Update Philip Bath & Joan Montaner

Meeting at Berlin, Germany April 2014

Title Presentor
Multi-PART Rationale & Purpose Emily Sena
WP2: Scientific Coordination Uli Dirnagl & Mhairi Macrae
WP3: Experimental Design Hanno Würbel
WP3: Experimental Design Denis Vivien
WP4: Regulation and Ethics update Stuart Allan & Nathalie Percie du Sert
WP5: Data management update Malcolm Macleod

Kick-off meeting at Edinburgh, UK, September 2013

Title Presentor
Multi-PART (Multicentre Preclinical Animal Research Team) Emily Sena
WP2: Scientific Coordination Uli Dirnagl & Mhairi Macrae
WP3: Experimental Design Hanno Würbel
WP4: Regulation and Ethics update Stuart Allan & Nathalie Percie du Sert
WP5: Data Management Anna Planas