CCBS : Centre For Clinical Brain Sciences

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Dr Colin Smith

Email

col.smith@ed.ac.uk

Telephone

+44 (0)131 651 5007

Fax

+44 (0)131 651 1345

Postal Address

Neuropathology, University of Edinburgh Wilkie Building, Teviot Place, Edinburgh, EH8 9AG

Job Title

Senior Lecturer in Pathology and honorary consultant neuropathologist

Speciality

Neuropathology

Qualifications

BSc, MBChB, MD, FRCPath

Research overview

My main areas of research are;

1/ Traumatic Brain Injury. This involves animal and human studies both locally and in collaboration with researchers at the University of Pennsylvania.

2/ Human Tissue banking. This involves the development of optimal storage of human tissues for DNA, RNA and protein studies.

Research direction

I am principally involved in the study of traumatic brain injury using animal models and autopsy derived human tissue. The main areas of interest relate to the molecular mechanisms underlying white matter injury and the responses of brain tissue to brain injury including age related changes. I am also looking at factors that may influence the long-term outcome, particularly neuroinflammation.

There are a number of brain and tissue bank facilities within Academic Neuropathology. I am involved in running the Sudden Death Brain and Tissue Bank. This bank has formed collaborative research with a number of local, national and international researchers. We are currently assessing epigenetic variation in the human population and proteomics of the synaptosome in psychiatric disorders.

Current research grants include;

  • Sudden Death Brain and Tissue Bank MRC, £591969 March 2007- February 2009
  • “Biomechanics of Pediatric Head Injury” NIH, $3,491,390 (5-year funding)
  • “Brain Injury Criterion for 6 to 10 year old children” NHTSA, $135,988 (3 year funding)

Board Membership
  • Professional Affairs Committee British Neuropathological Society
  • Editorial Board “Neuropathology and Applied Neurobiology”
Recent Publications
  • Leaver HA, Williams JR, Smith C, Whittle IR (2004) Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. Prostoglandins, Leukotrienes and Essential Fatty Acids 70: 449-453.
  • Smith C, Whitwell HH (2004) Non-traumatic neurological conditions in medico-legal work. Current Diagnostic Pathology 10: 116-127.
  • Whittle IR, Smith C, Navoo P, Collie D (2004) Meningiomas. Lancet 363:1535-1543.
  • Suresh E, Dhillon VB, Smith C, Ironside JW (2004) A Case of Churg-Strauss vasculitis diagnosed on muscle biopsy. J Clin Path 57: 334.
  • Gentleman SM, Leclercq PD, Moyes L, Graham DI, Smith C, Griffin WS, Nicoll JA (2004) Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Int 146: 97-104.
  • Graham DI, Smith C, Reichard R, Leclercq PD, Gentleman SM (2004) Trials and tribulations of using beta-amyloid precursor protein immunohistochemistry to evaluate traumatic brain injury in adults. Forensic Sci Int 146: 89-96.
  • Quinn TJ, Smith C, Murray L, Stewart J, Nicoll JA, Graham DI (2004) There is no evidence of an association in children and teenagers between the apolipoprotein E epsilon4 allele and post-traumatic brain swelling. Neuropathol Appl Neurobiol 30: 569-575.
  • Whiteley WN, Rudge P, Smith C, Warlow CP (2004) An elderly man with cranial nerve palsies, otalgia and otorrhoea. Practical Neurology 4: 332-339.
  • O'Reilly BF, Kishore A, Crowther JA, Smith C (2004) Correlation of growth factor receptor expression with clinical growth in vestibular schwannomas. Otol Neurotol 25: 791-796.
  • Willis J, Smith C, Ironside JW, Erridge S, Whittle IR, Everington D (2005) The accuracy of meningioma grading: a 10-year retrospective audit. Neuropath Appl Neurobiol 31: 141-149.
  • Kurian KM, Summers DM, Statham PF, Smith C, Bell JE, Ironside JW (2005) Third ventricular chordoid glioma: clinicopathological study of two cases with evidence for a poor clinical outcome despite low grade histological features. Neuropathol Appl Neurobiol. 31: 354-361.
  • Reichard RR, Smith C, Graham DI (2005) The significance of beta-APP immunoreactivity in forensic practice. Neuropathol Appl Neurobiol 31: 304-313.
  • Higgins GS, Smith C, Summers DM, Statham PFX, Erridge SC (2005) Myxopapillary ependymoma with intracranial metastases. Br J Neurosurg 19: 356-358.
  • Smith C, Graham DI, Murray LS, Stewart J, Nicoll JAR (2006) Association of APOEe4 and cerebrovascular pathology in traumatic brain injury. J Neurol Neurosurg Psychiatry 77: 363-366.
  • Murray K, Shorvon S, Smith C, Roberts R, Warlow C (2006) A young man with bilateral epilepsia intractable and partialis continua. Practical Neurology 6: 34-41.
  • Heath CA, Barker RA, Esmonde TF, Harvey P, Roberts R, Trend P, Head MW, Smith C, Bell JE, Ironside JW, Will RG, Knight RS (2006) Dura mater-associated Creutzfeldt-Jakob disease: experience from surveillance in the UK. J Neurol Neurosurg Psychiatry
  • Friess SH, Ichord RN, Owens K, Ralston J, Rizol R, Overall KL, Smith C, Helfaer MA, Margulies SS (2007) Neurobehavioral functional deficits following closed head injury in the neonatal pig. Exp Neurol 204: 234-43.
  • Millar T, Walker R, Arango JC, Ironside JW, Harrison DJ, MacIntyre DJ, Blackwood D, Smith C, Bell JE. Tissue and organ donation for research in forensic pathology: the MRC Sudden Death Brain and Tissue Bank. J Pathol. 2007; 213:369-75.
  • Erridge SC, Kerr GR, Hart M, Smith C, McNamara S, Whittle IR, Grant R, Gregor A. Audit of patients with glioma referred to edinburgh cancer centre 1988-2002: pathology, treatment and outcome. Clin Oncol (R Coll Radiol). 2007; 19(3 Suppl):S28.
  • Whittle IR, Short DM, Deighton RF, Kerr LE, Smith C, McCulloch J. Proteomic analysis of gliomas. Br J Neurosurg. 2007;21:576-82.
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